He formed Gnarls Barkley with Cee Lo Green and produced their albums St. Elsewhere and The Odd Couple. He produced the second Gorillaz album, 2005's Demon Days, as well as Beck's 2008 record, Modern Guilt and an album with Joker's Daughter in 2007. He has been nominated for a Grammy Award in the Producer of the Year category five times (2005, 2006, 2009, 2010, 2011), and won the award in 2011. In addition, Burton worked with rapper MF Doom as Danger Doom and released the album The Mouse and the Mask and the EP Occult Hymn.
In 2009 he collaborated with James Mercer of the indie rock band The Shins to form Broken Bells. The group's first album was released on March 9, 2010.
Danger Mouse was listed as one of Esquire magazine's seventy-five most influential people of the 21st century. In 2010 he began producing an album for U2.
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