Although Clapton has varied his musical style throughout his career, it has always remained grounded in the blues. Yet, in spite of this focus, he is credited as an innovator in a wide variety of genres. These include blues-rock (with John Mayall & the Bluesbreakers and The Yardbirds) and psychedelic rock (with Cream). Clapton's chart success was not limited to the blues, with chart-toppers in Delta Blues (Me and Mr. Johnson), pop ("Change the World") and reggae (Bob Marley's "I Shot the Sheriff") (He is often credited for bringing reggae and Bob Marley to the mainstream.) Two of his most successful recordings were the hit love song "Layla", which he played with the band Derek and the Dominos, and Robert Johnson's "Crossroads", which has been his staple song since his days with Cream.
From Wikipedia







Derek and the Dominos
B.B. King & Eric Clapton
Cream
John Mayall & The Bluesbreakers
B.B. King
J.J. Cale & Eric Clapton
Blind Faith
Stevie Ray Vaughan and Double Trouble









