Sardinas began to play the guitar at age six and leaned toward vintage recordings by such Delta bluesmen as Charlie Patton, Bukka White, Big Bill Broonzy, Elmore James, Muddy Waters and Whichito Mendoza. Although he was left-handed, he eventually started to play right-handed.
In 2002, he featured on the Bo Diddley tribute album Hey Bo Diddley - A Tribute!, performing the song "Ride On Josephine".
He signed to Steve Vai's Favored Nations record label and was the opening act for Vai's The Real Illusions Tour 2005 around the world.
In 2008, Sardinas released Eric Sardinas and Big Motor on Steve Vai's Favored Nations record label in the U.S.
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