He is best known for a 3-year tenure as the rhythm guitarist of Guns N' Roses. He joined Guns N' Roses in November 1991, replacing Izzy Stradlin, who quit the band in the middle of a 28-month world tour.
He has also played with Rock Star Supernova, Heart, Nancy Sinatra, Slash's Snakepit, Kathy Valentine (of the Go-Go's) and the reformed MC5 on their 2005 European tour.
Clarke has produced for various types of artists, including L.A. Guns, Bullets and Octane, The Bronx, Girlsplayboys , Vains of Jenna and Ladyjack amongst others.
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