A mutant with the ability to create instant duplicates or "dupes" of himself, Madrox was largely a minor or supporting character until his appearance in the 1987 miniseries Fallen Angels. The character underwent greater development under writer Peter David through his appearance in David's run of the monthly series X-Factor (vol. 1) in the 1990s, and in David's second and currently ongoing run of the title (vol. 3) in the 2000s.
Multiple Man appears in the 2006 film, X-Men: The Last Stand, in which he was portrayed by Eric Dane.
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