During the hiatus of the group, Rowland collaborated with rapper Nelly on the single "Dilemma," a worldwide number-one hit, and released her rock pop-influenced debut solo album Simply Deep in 2002. It became a commercial success, selling more than two million copies worldwide, and garnered three more or less successful singles, among "Stole" and "Can't Nobody." Following the formal disbandment of Destiny's Child in 2005, Rowland's often-delayed second album, Ms. Kelly, was released in 2007. Moderately successful on the charts, it spawned the hit singles "Like This" and "Work." In 2009, she scored another number-one hit with her contribution on French DJ David Guetta's single "When Love Takes Over."
In 2002, Rowland branched into acting, which led to guest stints on sitcom series such as The Hughleys and Girlfriends, and leading roles in big-screen movies like Freddy vs. Jason (2003) and The Seat Filler (2004). In 2009, she became the host of the Bravo competition series The Fashion Show alongside Isaac Mizrahi.
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