After a return to college to focus on her studies, Hesketh along with two of her fellow students formed the electropunk band Dead Disco. The band had limited releases of their four singles but due to increasingly different ideas about the band's musical direction Hesketh left to pursue a solo career. Hesketh has cited as influences The Human League, Gary Numan, Kraftwerk, Pink Floyd, Kylie Minogue, Britney Spears and Jean Michel Jarre.
Hesketh began writing her own songs and posting covers on the social networking sites such as YouTube and Myspace. After appearing on several shows including Later... with Jools Holland and Last Call with Carson Daly, Hesketh entered production on her debut album Hands. With increasing media attention regarding her then-yet-to-be-released debut album, Hesketh topped the BBC Sound of 2009 poll and received a Critics' Choice nomination at the 2009 BRIT Awards. With the release of her debut, she was linked to a recent wave of breakthrough female artists in their twenties playing 1980s-influenced music, including Lady Gaga, Ladyhawke, Florence and the Machine and Elly Jackson of La Roux.
Her debut album, Hands, released on 8 June 2009, peaked at number five on the UK Albums Chart and at number twenty on the Irish Albums Chart. The first single off the album "New in Town" became a top twenty hit, while the next single "Remedy", produced by RedOne, reached the top ten. She has also released the EP Illuminations in the United States.
Her second album is scheduled to be released in sometime during 2012.
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