The group was formed when Urine was joined by fellow musicians guitarist Steve, second guitarist and brother Markus Euringer (soon to be replaced by bassist Vanessa Y.T, who was later replaced by Lyn-Z), and drummer Kitty in 1997. They have released four albums, two EPs, one live album, and one live DVD. Rather than signing traditional record contracts, the band has licensed most of their albums to record labels, retaining ownership of the music.
The group maintains a devout fanbase, and has opened for many well-known acts such as Linkin Park, My Chemical Romance, System of a Down, Korn, Sum 41, Insane Clown Posse and Rammstein. Notable bands who have opened for them include The Dresden Dolls, Rasputina, mc chris, The Birthday Massacre, Tub Ring and Dog Fashion Disco.
In January 2009 the band headlined the Kerrang! Relentless Energy Drink tour.
In December 2010, they released a comic entitled 'Adventures Into Mindless Self Indulgence' about various tour stories and significant moments of the band's career.
In an interview, frontman Jimmy Urine stated that there would be "an MSI surprise" for fans in 2011 which turned out to be a release of a remastered CD/DVD version of the band's first full length album Tight, called "Tighter", with several bonus tracks and recordings from their early days.
On October 30, 2011, they announced they would tour the United States starting on March 3, 2012 and lasting until April 1, 2012.
In May 2012, Mindless announced a tour of Europe lasting from 10-25-12 to 11-10-12.
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