O'Kelly was born in Cincinnati, Ohio. During his tenure, O'Kelly sometimes sang lead vocals on some of the Isley Brothers songs including "Black Berries" and "Let Me Down Easy" showcasing a similar vocal to that of his younger brother Ronnie. He remained a dedicated member of the group from its 1954 inception until he suddenly died of a heart attack at age 48. O'Kelly's younger brothers Rudolph and Ronald dedicated their 1987 album, Smooth Sailing, to his memory.
Isley was a resident of Alpine, New Jersey. He died in Alpine, New Jersey, and is buried in George Washington Memorial Park in Paramus, New Jersey.
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