Brand achieved mainstream fame in the UK in 2004 for his role as host of Big Brother spin-off, Big Brother's Big Mouth. His first major film role was in the 2007 film St Trinian's. He became known to American audiences when he got a major role in Forgetting Sarah Marshall which led to a starring role in 2010's Get Him to the Greek. He has also been a voice actor for animated films such as 2010's Despicable Me and the 2011 film Hop. He starred in the 2011 remake of the 1981 Dudley Moore film Arthur.
Brand is noted for his eccentricity and his controversies in the British media, including his dismissal from MTV for dressing up as Osama bin Laden and controversies while presenting at various award ceremonies, as well as his former substance abuse. The 2008 prank telephone calls he made to Andrew Sachs while co-hosting The Russell Brand Show with Jonathan Ross led to his resignation from the BBC and major policy changes in that organisation. His prior drug use, alcoholism and promiscuity influenced his comedic material and public image. He married American pop singer Katy Perry in October 2010, and filed for divorce from her in December 2011.
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