They were signed to Def Jam Records and went on to release their second studio album Every Six Seconds. Saliva later released their third studio album titled Back Into Your System on November 12, 2002 which reached #19 on the Billboard 200. Back Into Your System launched one of Saliva's most successful songs, "Always", reaching #51 on the Billboard Hot 100 and #1 on the Modern Rock Chart. Three years after Survival of the Sickest, Saliva released Blood Stained Love Story on January 23, 2007 repeating Back Into Your System's chart performance at #19 on the Billboard 200. Its first single, "Ladies And Gentlemen", peaked at #2 on the Mainstream Rock Chart.
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