TMBG's best-known songs include "Birdhouse in Your Soul" and their cover version of "Istanbul (Not Constantinople)" (both from the 1990 album, Flood), "Don't Let's Start" (from 1986's They Might Be Giants), and "Ana Ng" (from 1988's Lincoln). Their appearances on the television show Tiny Toon Adventures also brought attention to their songs "Particle Man" and "Istanbul". Their song "Doctor Worm" was a surprise hit in Australia, ranking 13th in the Triple J Hottest 100 for the year 1998. Two TMBG albums have been certified gold: Flood and the 2005 children's music album Here Come the ABCs. Flood has also been certified platinum.
Their song "Boss of Me" served as the theme to the Fox Television Network comedy series Malcolm in the Middle and earned them a Grammy Award in 2002. They have also contributed theme songs to Comedy Central's The Daily Show, The Oblongs, adult swim's The Drinky Crow Show, Disney Channel's Mickey Mouse Clubhouse and Higglytown Heroes, along with a commercial for Cartoon Network's shows Dexter's Laboratory and Courage the Cowardly Dog.
The band was the subject of the 2003 documentary film Gigantic (A Tale of Two Johns), directed by AJ Schnack. The band has sold over 4 million records in total.
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