Reynolds and director Tim Miller had enjoyed a close relationship while making the original film

Deadpool director Tim Miller has pulled out of the sequel.

Though he and Ryan Reynolds enjoyed a close relationship while making the original film, sources have told The Hollywood Reporter that “creative differences” have prompted Miller’s exit from the sequel.

Made for an estimated $60 million (£45 million) – small for a superhero movie – this year’s Deadpool went on to gross a massive $780 million (£595 million) worldwide. The sequel is due to start shooting in early 2017.

Reynolds was credited as a producer on the original film, but his influence is said to have grown “exponentially” on the sequel. He and Miller are reported to have “increasingly butted heads over certain creative issues”.

Meanwhile, Reynolds and the film’s other producers are reportedly in the process of casting the film’s female lead, popular Marvel mutant Domino.

Numerous actresses have tested for the role according to recent reports, including Sienna Miller, Ruby Rose, Lizzy Caplan and Sofia Boutella.

Deadpool 2 currently has no official title or release date. Rhett Reese and Paul Wernick, who wrote the original film, are also scripting the sequel.

Producer Simon Kinberg recently said of the sequel: “I think Deadpool 2 will comment on anything that’s happening in movies today especially in superhero movies. The sort of glut or saturation of these movies and the proliferation of sequels is definitely something we’ll play around with.”