The surprise appearance from the rock icon comes during a new episode which sees Fred, Scooby, Velma, Daphne and Shaggy taking a trip down Route 66. However, the trip soon takes a turn for the worst when a group of villains steal the Mystery Machine.
After finding themselves stranded in the desert, the gang enters a diner to use the Wi-Fi and spot Rose chilling outside the restaurant on his motorbike.
The GnR frontman is hailed as a “singer, songwriter, musician and total rock God”, before it transpires that he’s already firm friends with Shaggy and Scooby.
As Consequence of Sound reports, Rose then takes a pivotal role in solving the mystery of the villainous mudmen who are plaguing the group.
Rose’s latest foray into the cartoon world comes after he previously appeared in a 2018 episode of Looney Tunes, where he asked Bugs Bunny for directions to a gig he was due to perform with his fictional band, Steel Underpants.
Slash recently revealed that he’s expecting new GnR music to emerge at some point this year.
“Duff [McKagan] and I did some jamming and we also worked on the Guns record, and I’ve had a couple of ancillary recordings and jams on top of that, so there’s been a lot of stuff going on. I’m really not good at slowing down and just sitting around,” he said.
He added: “I would like to think that we’d have some new stuff out next year. It’s hard to say, but I would like to think we’ll have stuff out next year.”