The band are finishing a phenomenal year with two sold-out shows at the arena
Dirty Hit labelmate The Japanese House, aka Amber Bain, opened the night, playing tracks from recent EP 'Swim Against The Tide' and more.
After playing a drone for the minutes before they walked on stage, the band opened their set with second album tracks 'Love Me' and 'UGH!'.
"I'm here to celebrate being a fucking LEGEND," frontman Matty Healy said early on in the night, doing a twirl as he did.
He then went on to make a speech about "young, progressive voices of change being drowned out by regressive ideals" ahead of 'Loving Somebody'. "If we are the liberals, if we are the left, if we are the young, the black, the Muslim, the gay, whatever we are, we have to understand that all of this shit, these paradigms of race and all this kind of stuff, it seems to make sense but that’s not really what it’s about," he added, telling the crowd it was "our responsibility" to be pissed off, compassionate and understanding.
The group also played a host of older tracks throughout the night, reminding fans of their journey to the massive venue.
The likes of 'Milk', 'Undo', 'An Encounter' and 'M.O.N.E.Y.' all featured in the setlist, nestled between 'I Like It When You Sleep...''s instrumentals and pop hits.
The band's impressive production was stepped up from their UK tour earlier in the year, with one particularly stunning backdrop showing mirrored panels rotating through a beam of light.
They returned to play four more songs, opening with 'Medicine' and gospel-inspired 'If I Believe You'. They then brought the night to a close with jubilant versions of 'Chocolate' and 'The Sound'.